Erik ten Hag has confirmed Casemiro and Bruno Fernandes will both start against Real Betis on Thursday despite being a yellow card away from suspension.
The Red Devils have a commanding lead in their last 16 tie having sealed a 4-1 victory over the La Liga club at Old Trafford last Thursday.
Fernandes and Casemiro are both a booking away from getting a suspension that would rule them out of the first leg of the Europa League quarter-finals – should they make it to the last eight.
The Brazilian star missed a key game against Arsenal in similar circumstances in the January window, picking up a booking in a match against Crystal Palace four days earlier.
Despite the temptation to rest key players with an FA Cup quarter-final with Fulham also looming on Sunday, ten Hag says both players will start tomorrow night in Seville.
‘They will play,’ ten Hag told a press conference on Wednesday.
‘It is a very good opponent, last week we had a good result but we have to go again and we need our best players. We need a win and we need our best team.’
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However, United will be without Alejandro Garnacho for Thursday’s game with the winger facing weeks on the sidelines as the result of the ankle injury suffered in the draw against Southampton.
‘He [Garnacho] will be back before the end of the season,’ ten Hag said of the youngster. ‘We need to get him back as soon as possible and we hope he is ready.’
Antony has also not travelled to Spain with ten Hag confirming he misses out through illness. Anthony Martial is another player who has not made the trip.
“We can manage. We have players that can recover good in between games. We are in contact with medical and performance about what players can handle. We can mix it.
‘When we are going into the final stages of the season, we can bring our best team.’