Chelsea defender Ben Chilwell will play no part in the game against Denmark after leaving England’s training camp early with a foot injury.
The 23-year-old missed England’s previous Nations League 2-1 win over Belgium after coming down with an illness and had been training alone.
Kieran Trippier started at left wing-back in place of Chilwell as they came from behind to beat Belgium at the weekend but the Atletico Madrid player has now left England’s camp due to a personal issue.
According to Sky Sports, Chilwell’s foot injury is a pre-existing issue and the player’s fitness will be closely assessed by Chelsea ahead of an important few weeks for the club.
Chelsea will play Southampton when the Premier League returns next weekend before kicking off their Champions League campaign against Sevilla.
England skipper Harry Kane is set to return to Gareth Southgate’s starting lineup after recovering from a muscle injury.
‘Well, medically, there’s been conversations, because that would always be the case,’ Southgate replied when asked whether he had spoken to Tottenham about Kane’s fitness.
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‘He reported on the Sunday, we gave players that reported on Sunday, who weren’t involved in the Wales game for us, we gave them two days’ recovery.
‘He started to train on the Wednesday, was a little unhappy with how he felt, so then worked with our medical team the next couple of days, we scanned just to be certain but it’s a muscular fatigue issue rather than an injury, so it just needed a bit more confidence.
‘He knew by then he could push on a little bit, but he just needed a bit more confidence in it, and so his training week really wasn’t suitable to start the game.
‘I think he’ll have gained more confidence from the spell he had against Belgium, and so all being well, we hope he’ll be good to start on Wednesday.’